Everyone's favorite yellow canary unexpectedly becomes next in line for the crown when the queen of an island paradise disappears. His Little Highness’ entourage includes motorbike daredevil Granny and sly Sylvester, whose allegiance is tested when he uncovers a sinister plot to eliminate Tweety for good.

After scientists discover a mysterious substance that can influence human minds, two factions wage an all-out battle to control its awesome power.